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Targeting NAD+ Salvage Pathway as a Potential Approach to Combat Obesity
15 мар 2024
Нацеливание на путь спасения НАД+ как потенциальный подход к борьбе с ожирением
Introduction Mar 4th is determined as the World Obesity Day. World Obesity Federation, UNICEF and WHO have hosted a global youth-led webinar to talk about obesity & youth. The obesity crisis has gradually attr
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Tailoring Personalized Dosage Regimens of NMN Based on NAD Concentration
13 мар 2024
Разработка индивидуальных режимов дозирования НМН в зависимости от концентрации НАД
Introduction Nicotinamide mononucleotide (NMN), one precursor of nicotinamide adenine dinucleotide (NAD+), has been ascertained to be implicated with multiple biological processes such as cellular redox regulation and
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NR as a Promising Therapeutic Candidate for Alpers' Disease
12 мар 2024
НР как перспективный терапевтический кандидат при болезни Альперса
Introduction Alpers' disease is both a neurodegenerative disorder and a metabolic disorder, which is tightly linked to mitochondrial dysfunction and mutations in the catalytic subunit of polymerase
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Deep Insight on NADH: a Potential Medical Arsenal
11 мар 2024
Глубокий взгляд на NADH: потенциальный медицинский арсенал
  Introduction NADH (reduced form of NAD+) serves as a carrier of biological hydrogen and an electron donor, which participates in diverse physiological processes such as protein synthesis, DNA repair,
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Frontier Dynamics on the Molecular Mechanism of Ginsenoside Rh2 Against Tumor
07 мар 2024
Пограничная динамика молекулярного механизма гинзенозида Rh2 против опухоли
  Introduction Ginsenoside Rh2, one protopanaxadiol (PPD)-type rare ginsenoside in Panax ginseng, is uncovered to possibly have broad-spectrum pharmacological activity in diversified tumors. It is utili
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SLC25A51 Functions as an NAD+/NADH Redox Decoupler in AML
05 мар 2024
SLC25A51 Функционирует как окислительно-восстановительный разделитель NAD+/NADH в AML
Introduction Solute carrier family 25 member 51 (SLC25A51) is perceived as a mammalian transporter, which is capable of importing oxidized nicotinamide adenine dinucleotide (NAD+) into mitochondrial matrix. Remark
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The Molecular Mechanisms Underlying the Interaction Between NAD+/NMN and DBC1
04 мар 2024
Молекулярные механизмы, лежащие в основе взаимодействия между НАД+/НМН и ДБК1
Introduction Oxidized form of nicotinamide adenine dinucleotide (NAD+) and its precursor nicotinamide mononucleotide (NMN) have been uncovered to restore DNA repair and prevent cancer progression via the deleted i
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Protective Role of NAD+ Against MI-induced HF in Sprague-Dawley Rats and Beagles
29 фев 2024
Протективная роль НАД+ против СН, индуцированной инфарктом миокарда, у крыс и биглей Спрэга-Доули
1. Introduction Disrupted nicotinamide adenine dinucleotide (NAD+) metabolism is increasingly deemed to be one of risk factor for amendable cardiovascular disorders. A substantial evidence has mirrored that res
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Investigating the Great Possibility of Rare Ginsenosides as Drugs and Nutraceuticals
28 фев 2024
Исследование возможностей использования редких гинзенозидов в качестве лекарственных средств и нутрицевтиков
1. Introduction Rare ginsenosides, a group of dammarane triterpenoids that exist in low natural abundance, fuels a high concern from scholars recently, showing great potential as shining components in drugs and nu
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